Dose-related inhibition by dietary phenethyl isothiocyanate of esophageal tumorigenesis and DNA methylation induced by N-nitrosomethylbenzylamine in rats
References (34)
- et al.
The effects of ellagic acid and 13-cis-retinoic acid on N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats
Cancer Lett.
(1991) - et al.
Effects of dietary aromatic isothiocyanates fed subsequent to the administration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumorigenicity in mice
Cancer Lett.
(1990) - et al.
Effect of frequency of isothiocyanate administration on inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary adenoma formation in mice
Cancer Lett.
(1992) - et al.
Glucosinolates in crucifer vegetables: turnips and rutabagas
J. Agric. Food Chem.
(1981) - et al.
Effects of dietary compounds on α-hydroxylation of N-nitrosopyrrolidine and N′-nitrosonornicotine in rat target tissues
Cancer Res.
(1984) - et al.
Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone α-hydroxylation and DNA methylation in rat liver
Carcinogenesis (London)
(1985) - et al.
Effect of phenethyl isothiocyanate on the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured rat lung tissue
Carcinogenesis
(1991) - et al.
Erzeugung von karzinoman der speiserohre durch unsymmetrische nitrosamine
Naturwissenschaften
(1963) - et al.
Organotrope carcinogene wirkungen bei 65 verschidenen N-nitroso-verbindungen an BD-ratten
Z. Krebsforsch.
(1967) - et al.
Carcinogen in a Transkeian Bantu food additive
Nature
(1969)
Improved isolation of glucobrassicin and other glucosinolates
J. Sci. Food Agric.
Effect of phenethyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities
Xenobiotica
Esophageal carcinogenesis in F344 rats by nitrosomethylethylamines substituted in the ethyl group
J. Nat. Cancer Inst.
Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid
Carcinogenesis (London)
Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA adduct formation and tumorigenicity in the lung of F344 rats by dietary phenethyl isothiocyanate
Cancer Res.
Effect of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung
Cancer Res.
Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in mice by arylalkyl isothiocyanates
Carcinogenesis (London)
Cited by (77)
Chemistry of phosphorus ylides: Part 45 synthesis of phosphoranylidene, thietane, azetidine and thiazinane derivatives as potent chemo preventative agents
2018, Phosphorus, Sulfur and Silicon and the Related ElementsBiologically Active Isothiocyanates: Protecting Plants and Healing Humans
2017, Studies in Natural Products ChemistryCitation Excerpt :The synthesis of both enantiomers of (285) was achieved by conversion of the isonitrile group of 10-isocyano-4-cadinene (292) into the isothiocyanato function, using the synthetic method developed by Kambe et al. [26a] (Scheme 6.49). The enantioselective total synthesis of 10-isocyano-4-cadinene had been previously described by employing an intermolecular Diels-Alder reaction and a Barbier-type cyclization using samarium diiodide (SmI2) as the key steps, seen in Scheme 6.49 [240]. The absolute configuration of the synthesized compounds was established as (1S,6S,7R,10S)-10-isothiocyanato-4-cadinene (285) and its enantiomer (1R,6R,7S,10R)-10-isothiocyanato-4-cadinene (ent-285).
Cytoprotective Role of Dietary Phytochemicals Against Cancer Development via Induction of Phase II and Antioxidant Enzymes
2016, Advances in Molecular ToxicologyCitation Excerpt :The rate of formation of PEITC upon intake of cruciferous plant is approximately 30–67%. PEITC was reported to prevent or suppress the tumorigenesis in numerous studies conducted on animal models [166–169], and the effect was shown to be in a dose-dependent manner [170]. In addition to the anticarcinogenicity of PEITC, it was reported that a study on rats fed on PEITC with intake similar to the level of human consumption showed that this isothiocyanate had the capability to induce the carcinogen metabolizing enzymes epoxide hydrolase, glucuronosyl transferase, and sulfotransferase [69].
Antitumor activities of new iso(thio)cyanates and their nitrogen and sulphur heterocyclic phosphorus derivatives
2019, Journal of Applied Pharmaceutical Science