Another scientific study says Wasabi ingredient is biologically important
A study that has been published in the European Journal of Medicinal Chemistry stated that one of the unique chemicals found only in Wasabia japonica is biologically important.
In a paper entitled Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity, the authors acknowledged that the unique natural chemical only found in True Wasabi (Wasabia japonica) is biologically important to human health and kills Lung Cancer cells.
The Abstract states
Abstract
Reported is an enantiodivergent approach for the synthesis of both enantiomers of sulforaphane (SFN) homologues with different chain length between the sulfinyl sulfur and the isothiocyanate groups and different substituents on the sulfinyl sulfur. The homologues were designed in order to unravel the effect of all the diversity elements included in sulforaphane’s structure. The key step of the approach is the diatereoselective synthesis of both sulfinate ester epimers at sulfur, using as single chiral auxiliary the sugar derived diacetone-D-glucose. The approach allows the first synthesis of both enantiomers of 5-methylsulfinylpentyl isothiocyanate, and the biologically important 6-methylsulfinylhexyl isothiocyanate (6-HITC or 6-MITC) found in Japanese horseradish, wasabi (Wasabia japonica). The ability of the synthesized compounds as inductors of phase II detoxifying enzymes has been studied by determining their ability to activate the cytoprotective transcription factor Nrf2. The cytotoxic activity of all the synthesized compounds against human lung adenocarcinoma (A549) and embryonic lung fibroblasts (MRC-5) is also reported.
This is another study that shows Wasabi kills Cancer. In this case it was lung cancer.
The highlights of the report were
Highlights
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Both enantiomers of sulforaphane and six homologues were obtained.
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The ability of the synthesized compounds to activate the Nrf2 is studied.
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The cytotoxic activity of the analogues against cancer and healthy cells is reported.
Details of the study are shown below.
Sulforaphane homologues: Enantiodivergent synthesis of both enantiomers, activation of the Nrf2 transcription factor and selective cytotoxic activity
- a Instituto de Investigaciones Químicas, C.S.I.C-Universidad de Sevilla, C/. Américo Vespucio, 49, Isla de la Cartuja, 41092 Sevilla, Spain
- b Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain
- c Department of Biology, Institute of Molecular Health Sciences, ETH Zurich, Zurich, Switzerland
- d Departamento de Farmacología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain
- Received 2 July 2014, Revised 8 September 2014, Accepted 15 September 2014, Available online 16 September 2014
